An enormous research interest lies in the development of single-atom catalysts (SACs), which combine the advantages of homo- and heterogeneous catalysts. The outstanding performance of SACs can be attributed to the high surface energy of single-atoms on a solid support in comparison with bulk or nanomaterials. However, the high surface energy of SACs also results in the instability of the single-atoms and subsequent agglomeration. To address this key problem, a support engineering approach is pursued with the aim to stabilize SACs chemically on solid supports. This approach will not only be utilized for stabilization purposes, but also lays the basis for a tailored design of the adjacent chemical environment around the single-metal atoms and provides the possibility to tune the catalytic properties of SACs.